Continuing Dynamite's celebration of Vampirella's 45th anniversary! Upon learning of Vampirella being marked as a vessel for Lady Umbra, Demon-Queen of the Shadows, her contacts in Cestus Dei label her a threat and send an elite hit-squad of monster-killers--the Mallus Maleficarum, aka the Witch-Hammer--lead by the implacable Father Nicodemus, to dispose of her. With her world abruptly turned upside down, Vampirella finds herself unexpectedly allied with the strangest bedfellow imaginable.