As they travel across the globe on another mission, Subject 47 and his brother 6 begin to assemble their plan of attack against the Institute that made them who they are. A war on both their surrogate family of fellow subjects and a potential future spent as living weapons under someone else's control. While Diana Burnwood's new life in London has begun to blossom and her secret vendetta finds a new sponsor in the form of a crime boss all too eager to teach her new protege a few tricks how to get her hands dirty.