43% of the cells within a healthy human body belong to something other than the human host. Microbiomes, invasive bacteria, fungal and viral agents, and something else, something? more. When the BLOOM happened, humanity was changed forever, transformed by symbiotic fungal megasystems that infected their bodies. Some affected people grew new body parts, some found their personalities changed in radical new ways, while others reported contact with some? other intelligence not their own.

In this revolutionary new world, Agent Bayonetta finds herself investigating a series of mysterious murders, a chain of violence that leads her to a terrifying question on which the fate of every living being rests.