Croyd Crenson has been framed for murder in the New York City slum known as Jokertown. His only lead to find the real killer, the knowledge that whoever committed the crime has stolen vials of the trump virus, an antidote that can permanently reverse any joker's horrifying abnormalities, if its high failure rate doesn't kill them first. Meanwhile, Alex ventures out of the hospital to search for his missing friend, Kira. But he's about to find out how dangerous Jokertown can be!