Vixen and Animal Man journey into the sacred Tantu Totem to solve the mystery of their altered powers. But Anansi, the African spider god responsible for these changes, has only begun reshaping the powers and histories of the Justice League, as eight-year-old Bruce Wayne shoots the burglar who killed his parents, Wonder Woman retires from the JLA after the tragic death of her husband, Superman, and The Green Lantern Corps quarantines Earth after one of their number destroys an American city. With the team's history changing before Vixen's eyes, is the JLA we now know gone forever?