Strange Girl mixes the aesthetic elements of Preacher, Tank Girl and Hellboy with the desperate pace of The Road Warrior. Ten years after the Rapture, the Earth is unprotected by God, and the demonic citizens of hell have flooded our world, enslaving the remaining human population.

After saving the life of a runt demon named Bloato, bartender, occultist, and all around arse kicker Bethany Black discovers that God is soon returning to wipe the Earth clean of everything unholy. With the end of the world coming, Bethany and Bloato set out to find the last doorway left into heaven and plead for admission.