Hunger, Hatred, Domination, Oblivion, and Ruin. The world is dying, poised on the brink of falling to one of these great dooms. Factions pursue their own interests, as likely to be the heralds of the world's destruction as they are its saviors. Horrors – monstrous abominations that defy logic, science, and nature – roam the land. Bands of hunters follow bold leaders, seeking out and destroying Horrors, gaining fame as word of their deeds spreads amongst the desperate survivors. Rival bands compete for prestige, clash over ideology, and pose as much of a threat to each other as the Horrors they hunt.

The Doomed is a quick-playing, rules-light skirmish wargame in which small warbands of hunters compete to hunt unique Horrors in a bleak sci-fi world. Scenarios are defined by the Horror being hunted and by the Conflict in which the hunt takes place. Each Horror has its own strengths, weaknesses, and tactics, often breaking the rules in unique ways, and must be approached carefully – stealth, cunning, and brute force will all have a role to play. Each Conflict, meanwhile, provides a distinct set-up for the scenario and a secondary objective that pits the warbands against each other as well as against the Horror. Campaigns build towards a climax, with hunters gaining prestige and renown, offering access to new, unique options for their warband. In the background, the five dooms also grow in power, threatening to deliver their own climax to the campaign if the hunters are not successful enough.